Fernanda Pilatti da Silva
Research Scientist | RD&I
Toledo
Summary
Resilient, meticulous and analytical researcher with almost three years of educational and hands-on experience in R&D preformulation. Adaptive and sociable team player with in-depth knowledge in polymorphism analysis, compatibility studies, analytical method validation, particle size analysis and problem-solving.
Overview
8
8
years of professional experience
7
7
years of post-secondary education
Work History
Junior Research Scientist
Prati Donaduzzi & Cia Ltda
Toledo
05.2021 - Current
- Characterize polymorphic forms of active pharmaceutical ingredients by Fourier Transform Infrared Spectroscopy (FTIR), thermal analysis (TGA/DSC, DSC), X-Ray Powder Diffraction (XRD);
- Analytical evaluation of IR spectra, thermal curves, diffractograms and particle size distribution profile (PSD);
- Investigation of the crystalline structure of drugs and possible polymorphic conversions for application in pharmaceutical formulations;
- Polymorphic screening performing;
- Develop compatibility studies between drugs and excipients for formulation;
- Development and analytical validation of particle size methods;
- Evaluate crystal morphology of active pharmaceutical ingredients by optical microscopy;
- In-depth scientific research for the development of analytical methods, polymorphic characterization and compatibility studies of active pharmaceutical ingredients;
- Report development of polymorphism, drug-excipient compatibility, pre-formulation, analytical validation methods to be submitted to the National Health Surveillance Agency (ANVISA - Brazil);
- Elaborate of scientific technical advice for the incorporation of new technologies — or new applications for existing technologies;
- Correct and discuss of analytical method protocols, reports and scientific technical advice;
- In-depth knowledge of Brazilian legislation for the development and application of analytical methods for new drugs and generic drugs;
- In-depth knowledge on application of ICH in the pharmaceutical industry;
- Method analysis certificate evaluation of raw material suppliers;
- Contact and meeting with suppliers of active pharmaceutical ingredients;
- Use of SAP (Systems Applications and Products) software;
- Streamline research processes to meet tight deadlines for multiple projects;
- Completed testing projects by deadline and under budget for company-wide initiatives;
- Recognize abnormal test results and devised corrective actions to retain accurate and valid results.
Junior Research Analyst
Prati Donaduzzi & Cia Ltda
Toledo
11.2019 - 04.2021
- Compared pharmaceutical active ingredient against design and production specifications through quality and integrity checks;
- Analyzed pharmaceutical active ingredient to evaluate nature, polymorphism, particle size and other factors affecting use in drug development applications;
- Composed technical reports and charts to document experimental test results;
- Developed methodologies to identify particle size in pharmaceutical products;
- Performed analysis of pharmaceutical finished products using XRPD method to test for polymorphism;
- Polymorphic characterization of active pharmaceutical ingredients by Fourier Transform Infrared Spectroscopy (FTIR), thermal analysis (TGA/DSC, DSC), X-Ray Powder Diffraction (XRD);
- Analytical evaluation of IR spectra, thermal curves, diffractograms and particle size distribution profile (PSD);
- Investigation of the crystalline structure of drugs and possible polymorphic conversions for application in pharmaceutical formulations;
- Polymorphic screening performing;
- Compatibility studies between drugs and excipient for formulation development;
- Evaluation of crystal morphology of active pharmaceutical ingredients by optical microscopy;
- Report development of polymorphism, drug-excipient compatibility, analytical validation methods to be submitted to the National Health Surveillance Agency (ANVISA - Brazil);
- Elaboration of scientific technical advice for the incorporation of new technologies — or new applications for existing technologies;
- Correction and discussion of analytical method protocols, reports and scientific technical advice;
- Method analysis certificate evaluation of raw material suppliers;
- Contact and meeting with suppliers of active pharmaceutical ingredients;
- Use of SAP (Systems Applications and Products) software.
PhD in Pharmaceutical Science
State Unversity of Maringá
Maringá - PR and Münster - NW
02.2018 - 07.2022
- Gathered, reviewed and summarized literature from scientific journals such as SciFinder and PubMed and produced graphs and other scientific calculations using MS Excel and Prisma;
- Maintained laboratory operations, updating and revising standardized operating procedures and reordering raw materials and supplies to sustain experiments and workflow;
- Performed analytical experiments and research and documented findings;
- Produced extracts of herbal plants using homogenizing disperser, rotaevaporator and lyophilizer;
- Performed separation of the constituents of the extract by column chromatography;
- Idealized and developed polymeric mucoadhesive matrix microparticles to obtain a modified release system;
- Elaborated a factorial planning in Statistica® software for the development of the modified release system;
- Produced microparticles in the spray dryer equipment;
- Worked in a cell culture laboratory;
- Performed a release assay in a modified Franz cell;
- Assessed antibacterial activity and antibiofilm formation in vitro;
- Conducted ELISA tests and other activity-based assays to characterize the mechanisms of action of the tested bacteria and its biology;
- Performed products characterization in HPLC, UHPLC, UPLC-MS;
- Led courses independently with minimal oversight from professors.
Master in Pharmaceutical Science
State University of Maringá
Maringá - PR
02.2017 - 02.2018
- Gathered, reviewed and summarized literature from scientific journals and produced graphs and other scientific calculations using MS Excel;
- Prepared herbal extracts using an homogenizing disperser, rotaevaporator, lyophilizer;
- Elaborated a mixture factorial planning in Statistica® software for the development of the nanometric system;
- Carried out characterization of the extract by HPLC;
- Developed liposome nanoparticles;
- Performed µ-DSC tests and interpreted the thermal curves;
- Performed particle size analysis in DLS and its morphology in microscopy;
- Assessed zeta potential in DLS;
- Performed in vitro tests with anaerobic bacteria.
Education
Bachelor of Science - Pharmacy
State University of Maringá
Maringá - PR - Brazil 02.2011 - 12.2015
Specialist - Pharmaceutical Sciences
State University of Maringá
Maringá - PR - Brazil 02.2016 - 02.2018
Skills
Polymorphism in APIs
Accomplishments
- Filed a patent at INPI numbered BR102020023491-9;
- Published a scientific paper in the journal Planta Medica (DOI: 10.1055/a-1858-6898);
- Published a scientific paper in the Revista Brasileira de Farmacognosia (https://doi.org/10.1007/s43450-021-00214-w).
Timeline
Junior Research Scientist
Prati Donaduzzi & Cia Ltda
05.2021 - Current
Junior Research Analyst
Prati Donaduzzi & Cia Ltda
11.2019 - 04.2021
PhD in Pharmaceutical Science
State Unversity of Maringá
02.2018 - 07.2022
Master in Pharmaceutical Science
State University of Maringá
02.2017 - 02.2018
Specialist - Pharmaceutical Sciences
State University of Maringá
02.2016 - 02.2018
Bachelor of Science - Pharmacy
State University of Maringá
02.2011 - 12.2015
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