Joyce Natividade Da Costa

• Supported Fiocruz's units by offering specialized counsel in intellectual property and administrative law.
• Tracked cases before the Tribunal de Contas da União, ensuring thorough legal defense.
• Evaluated and suggested improvements for Administrative Contracts, focusing on supply agreements.
• Engaged with Fiocruz's innovation center regarding legal concerns.
• Managing Fiocruz-related legal affairs.
• Enhanced support for the Technological Innovation Center of Fiocruz in technology transfer processes.
• Studied implications of partnerships in relation to technology transfers.
• Assessed legal aspects of patents in the context of administrative and technology transfer contracts.
• Reviewing legal and regulatory frameworks related to confidentiality and scientific disclosures of Fiocruz;
• Participating in defining negotiation parameters for technology transfer agreements;
• Drafting administrative orders related to confidentiality and scientific disclosures in alignment with Fiocruz guidelines.

• Preparation and prosecution of patent applications in Chemistry and Biotechnology sciences, focusing studies in New Plant Varieties protection worldwide.
• Intelligence analysis and strategic studies.
• IP Training and Portfolio Management.
• Freedom to operate (patentability, non-infringement, invalidity and unenforceability) and opinions thereon
• Litigation support in intellectual property matters
• Complex transactions involving: planning a licensing strategy, and negotiating and drafting sophisticated patent, know how and trademark licensing agreements for licensees and licensors
• Technology roadmaps – This kind of work describes the steps that the organisation needs to achieve their stated goals. In this sense, it helps the company to know the environments of the main s emergent technologies.

• Development of work in the field of intellectual property;
• Engagement in prospecting companies in the healthcare sector;
• Participation in providing guidance for the drafting of legal instruments for national and international companies regarding intellectual property assets;
• Consultancy services related to negotiations in the field of intellectual property and the protection of intellectual property assets based on current legislation;
• Participation in negotiations, drafting, and guidance related to the national and international legal protection of intellectual property assets.

• Preparation and prosecution of patent applications in Chemistry and Biotechnology sciences, focusing studies in New Plant Varieties protection worldwide.
  Intelligence analysis and strategic studies.
• IP Training and Portfolio Management.
• Patent Interference matters
• Appeals from the Board of Appeals and Interferences to the Court of Appeals for the Federal Circuit
  Investigation of infringement, validity and enforceability matters, and opinions thereon
• Right to use investigations (patentability, non-infringement, invalidity and unenforceability) and opinions thereon
• Litigation support in intellectual property matters
• Complex transactions involving: planning a licensing strategy, and negotiating and drafting sophisticated patent, know how and trademark licensing agreements for licensees and licensors

Researches on the enzymatic activities of CD39 and CD73 play strategic roles in calibrating the duration, magnitude, and chemical nature of purinergic signals delivered to immune cells through the conversion of ADP/ATP to AMP and AMP to adenosine, respectively. This drives a shift from an ATP-driven proinflammatory environment to an anti-inflammatory milieu induced by adenosine. The CD39/CD73 pathway changes dynamically with the pathophysiological context in which it is embedded. It is becoming increasingly appreciated that altering this catabolic machinery can change the course or dictate the outcome of several pathophysiological events, such as AIDS, autoimmune diseases, infections, atherosclerosis, ischemia–reperfusion injury, and cancer, suggesting these ectoenzymes are novel therapeutic targets for managing a variety of disorders.

Polyphenols such as Resveratrol (Rv) are well known as lifespan enhancers in all organisms studied so far. Mosquitoes continuously feed on sugars and polyphenols regularly present on vegetal fluids. Thus we are testing the effect of Rv on Aedes aegypti diet in order to map signaling mechanism that may naturally enhance mosquito lifespan. This may lead to novel strategies to block disease transmission by such organisms. The survival of Rv-fed A. aegypti increased up to 40% in females and 30% in males. Bacterial population isolated from A. aegypti midgut was 50% decreased by Rv. These bacterias are not directly affected by Rv exposition in vitro. This finding suggests that Rv may regulate mosquito midgut anti-microbial activity although we did not found any differences in reactive species or anti-microbial peptides expression. Protein phosphorylation on serine residues was largely affected by RV on mosquito abdomen and midgut. So we have investigated Rv-mediated regulation on triglyceride (TG) metabolism. TG reserves were 50% diminished by Rv probably by modulation of AMP-dependent protein kinase activity as evaluated by immunoblotting towards this enzyme. The suppression on fatty acid synthesis is corroborated by an increase on coupling of mitochondrial preparations. Altogether these data show for the first time that polyphenols may be key molecules to control mosquito lifespan